The Pee Dee River, also known as the Great Pee Dee River, is a river in North Carolina and South Carolina. It originates in the Appalachian Mountains in North Carolina, where its upper course above the mouth of the Uwharrie River is known as the Yadkin River, and it is extensively dammed for flood control and hydroelectric power. The lower part of the river is named Pee Dee (in colonial times written Pedee) after the Native American Pee Dee tribe. The tribe or the river also give the name to the Pee Dee region of South Carolina, composed of the northeastern counties of the state.
The river is navigable up the fall line at Cheraw, South Carolina and was an important trade route from colonial time. The largest lumber company in the world existed at the turn of the 20th century near the river's mouth at Georgetown, South Carolina. The virgin pine forests of the Pee Dee region were cut over and the logs floated in rafts downriver to be sawn into lumber and exported to the northern USA and Europe.